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Organ-on-a-Chip.

Ilka Maschmeyer¹, Sofia Kakava²

¹TissUse GmbH, Berlin, Germany. ilka.maschmeyer@tissuse.com.

Advances in Biochemical Engineering/Biotechnology

|September 19, 2020

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New microfluidic devices called organs-on-chips are being developed to better model human physiology in vitro. These advanced systems aim to overcome limitations of traditional cell cultures and animal models in drug development.

Area of Science:

Biomedical Engineering
In Vitro Modeling
Drug Development

Background:

Current drug development tools like cell cultures and animal models have significant limitations in accurately reflecting human physiology.
Microfluidics technology is advancing the development of sophisticated in vitro models.

Purpose of the Study:

To discuss the potential of organ-on-a-chip and human-on-a-chip platforms as powerful tools for emulating human physiology.
To highlight the engineering and biological challenges hindering the widespread application of these advanced models.

Main Methods:

Review of current advancements in microfluidics for creating organ-on-a-chip systems.
Discussion of the integration of multiple organ models into a single platform.
Exploration of the ultimate goal of a human-on-a-chip system.

Keywords:

Bioengineering Disease modeling Drug development Human-on-a-chip Microfluidics Organ-on-a-chip

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Last Updated: Dec 8, 2025

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Scalable Fabrication of Stretchable, Dual Channel, Microfluidic Organ Chips

Published on: October 20, 2018

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

The Multi-organ Chip - A Microfluidic Platform for Long-term Multi-tissue Coculture

Published on: April 28, 2015

Main Results:

Organ-on-a-chip platforms represent a significant step towards in vitro human physiology emulation.
Integration of multiple organ models is progressing, with human-on-a-chip as the ultimate objective.
Several engineering and biological challenges impede the full realization and application of these technologies.

Conclusions:

Organ-on-a-chip technology holds immense potential for revolutionizing drug development and biomedical research.
Overcoming current challenges is crucial for the widespread adoption and success of these in vitro human models.