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Relationships between mitral annular calcification and cardiovascular events: A meta-analysis

Tom Kai Ming Wang1, Brian P Griffin1, Bo Xu1

  • 1Section of Cardiovascular Imaging, Heart and Vascular Institute Cleveland Clinic, Cleveland, OH, USA.

Echocardiography (Mount Kisco, N.Y.)
|September 19, 2020
PubMed

Insights

Mitral annular calcification (MAC) is linked to increased risks of death and major cardiovascular events. This finding highlights MAC

Area of Science:

  • Cardiology
  • Gerontology
  • Epidemiology

Background:

  • Mitral annular calcification (MAC) is common in older adults.
  • MAC is increasingly recognized for its links to cardiovascular disease risk and outcomes.
  • Its impact on valvular heart disease and interventions is a focus of current research.

Purpose of the Study:

  • To conduct a meta-analysis on the association between MAC and cardiovascular mortality and morbidity.
  • To quantify the relationships between MAC and adverse cardiovascular events.

Main Methods:

  • Searched PubMed, Cochrane, and Embase databases until November 30, 2019.
  • Included 26 studies with 35,070 participants.
  • Used random-effects models to pool data on MAC and cardiovascular outcomes.

Main Results:

  • MAC was associated with significantly higher all-cause mortality (HR 1.76) and cardiovascular mortality (HR 1.85).
  • MAC correlated with increased risks of myocardial infarction (HR 1.48), stroke (HR 1.51), heart failure (HR 1.55), and atrial fibrillation (HR 1.75).
  • Patients with MAC had a higher likelihood of mitral valve replacement during cardiac surgery (OR 2.82).

Conclusions:

  • Mitral annular calcification is associated with elevated rates of mortality and cardiovascular events.
  • The prevalence of MAC has significant clinical implications for cardiovascular risk stratification.
  • MAC presence warrants consideration in the management of valvular heart disease and interventions.
Abstract

Keywords:
echocardiographymitral annular calcificationmitral valve

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