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Inductively Coupled Plasma Atomic Emission Spectroscopy: Instrumentation01:26

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Inductively coupled plasma (ICP) is the common plasma source used in atomic emission spectroscopy (AES), a technique that detects and analyzes various elements in a sample. This method is often called inductively coupled plasma atomic emission spectroscopy (ICP-AES).
There are three main types of inductively coupled plasma atomic emission spectroscopy  (ICP-AES) instruments: sequential, simultaneous multichannel, and Fourier transform instruments, with the latter being less commonly used....
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Saxitoxin aptasensor based on attenuated internal reflection ellipsometry for seafood.

Mustafa Oguzhan Caglayan1, Zafer Üstündağ2

  • 1Bilecik Şeyh Edebali University, Bioengineering Department, Bilecik, Turkiye.

Toxicon : Official Journal of the International Society on Toxinology
|September 19, 2020
PubMed
Summary

This study introduces a novel label-free saxitoxin (STX) sensor utilizing aptamers and spectroscopic ellipsometry (SE) for rapid detection. The developed sensor accurately identifies STX in seafood with high sensitivity and low detection limits.

Keywords:
Attenuated internal reflection ellipsometryParalytic shellfish poisoning toxinSaxitoxinSeafoodSurface plasmon resonance

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Area of Science:

  • Analytical Chemistry
  • Biosensing Technology

Background:

  • Saxitoxin (STX) is a potent marine biotoxin posing significant risks to human health.
  • Accurate and sensitive detection methods for STX are crucial for food safety and environmental monitoring.
  • Existing detection methods may lack the sensitivity, speed, or real-time capabilities required for comprehensive monitoring.

Purpose of the Study:

  • To develop and validate a novel label-free sensor for the detection of saxitoxin (STX).
  • To utilize aptamer-based recognition in conjunction with spectroscopic ellipsometry (SE) and attenuated internal reflection (AIR) SE for enhanced sensitivity.
  • To compare the analytical performance of SE and AIR-SE for real-time STX detection in complex matrices.

Main Methods:

  • Development of a label-free sensor employing STX-specific aptamers immobilized on a sensor surface.
  • Utilizing surface plasmon resonance (SPR) conditions with spectroscopic ellipsometry (SE) for signal transduction.
  • Employing attenuated internal reflection (AIR) spectroscopic ellipsometry for enhanced sensitivity and real-time STX detection.

Main Results:

  • Achieved low limits of detection: 0.01 ng/mL for AIR-SE and 0.11 ng/mL for SE.
  • Demonstrated a wide operational detection range from 0.01 nM to 1000 nM for STX.
  • Successfully detected and quantified STX in real fish and shrimp samples with high accuracy and selectivity.

Conclusions:

  • The proposed aptamer-based AIR-SE sensor offers a highly sensitive and selective method for real-time STX detection.
  • Both SE and AIR-SE methods provide robust analytical performance suitable for STX monitoring in food safety applications.
  • This label-free approach presents a promising advancement in the field of marine toxin detection and biosensing.