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A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
Modelling the effects of the contaminated environments on tuberculosis in Jiangsu, China
Yongli Cai1, Shi Zhao2, Yun Niu3
1School of Mathematics and Statistics, Huaiyin Normal University, Huaian 223300 PR China.
Abstract:
Tuberculosis (TB) is still an important public health issue in Jiangsu province, China. In this study, based on the TB transmission routes and the statistical data of TB cases, we formulate a novel TB epidemic model accounting for the effects of the contaminated environments on TB transmission dynamics. The value of this study lies in two aspects. Mathematically, we define the basic reproduction number, R0, and prove that R0 can be used to govern the threshold dynamics of the model. Epidemiologically, we find that the annual average R0 is 1.13,>1 and TB in Jiangsu is an endemic disease. Therefore, in order to control the TB in Jiangsu efficiently, we must decrease the virus shedding rate or increase the recovery rates, and increase the environmental clearance rate.
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