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Brain structural changes in CADASIL patients: A morphometric magnetic resonance imaging study.

Hui Pan1, Qi Huang2, Shiyu Ban3

  • 1Department of Neurology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhizaoju Road, Shanghai, 200011, People's Republic of China.

Neuroscience Letters
|September 19, 2020
PubMed
Summary
This summary is machine-generated.

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients show reduced cortical thickness and white matter volume. More strokes correlate with thinner brain regions in this inherited small vessel disease.

Keywords:
Brain structural changesCADASILCortical thicknessGray matter volumeWhite matter volume

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Area of Science:

  • Neuroimaging
  • Neurology
  • Genetics

Background:

  • Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is an inherited cerebral small vessel disease.
  • Previous research indicates involvement of specific cortical regions in CADASIL.
  • Structural brain alterations and clinical correlations in CADASIL require further investigation.

Purpose of the Study:

  • To investigate structural brain alterations in CADASIL patients using advanced MRI techniques.
  • To explore the relationship between structural brain changes and clinical outcomes in CADASIL.

Main Methods:

  • Evaluated 22 CADASIL patients and 22 healthy controls.
  • Utilized 3.0-T MRI with surface- and voxel-based morphometry to assess gray and white matter.
  • Calculated correlations between structural data and clinical/MRI metrics.

Main Results:

  • CADASIL patients displayed reduced cortical thickness in multiple left-sided brain regions, including the supramarginal and temporal gyri.
  • Significant white matter volume reduction was observed across all lobes, unlike gray matter.
  • Increased stroke/TIA history correlated with decreased cortical thickness in specific brain areas.

Conclusions:

  • CADASIL is characterized by reduced cortical thickness and white matter volume compared to controls.
  • The number of strokes and TIAs is associated with regional cortical thinning in CADASIL patients.