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Non-coding RNA in thyroid cancer - Functions and mechanisms.
Jun Cao1, Mengdi Zhang2, Long Zhang2
1Department of Rare and Head and Neck Oncology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China.
Cancer Letters
|September 19, 2020
Summary
Thyroid cancer incidence is rising, with noncoding RNAs (ncRNAs) like microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) showing abnormal expression. This review explores their roles in thyroid cancer development and metastasis for new treatment strategies.
Area of Science:
- Endocrinology
- Molecular Biology
- Oncology
Background:
- Thyroid cancer is the most common endocrine malignancy, with increasing incidence.
- Noncoding RNAs (ncRNAs), including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), are increasingly implicated in thyroid cancer.
- While short ncRNAs like miRNAs are well-studied, the role of lncRNAs in thyroid cancer remains less understood.
Purpose of the Study:
- To review the roles and clinical significance of miRNAs, lncRNAs, and circular RNA in thyroid cancer.
- To highlight the involvement of these ncRNAs in thyroid development, tumorigenesis, and metastasis.
- To propose novel therapeutic strategies for thyroid cancer based on ncRNA research.
Main Methods:
- Literature review of recent studies on ncRNAs in thyroid cancer.
- Analysis of the expression patterns and functional roles of miRNAs, lncRNAs, and circular RNA.
- Examination of clinical significance and potential therapeutic applications.
Main Results:
- Abnormal expression of miRNAs, lncRNAs, and circular RNA is observed in thyroid cancer.
- These ncRNAs play critical roles in thyroid development, tumorigenesis, and metastasis.
- Specific ncRNAs show potential as diagnostic biomarkers and therapeutic targets.
Conclusions:
- ncRNAs represent a promising area for understanding and treating thyroid cancer.
- Further research into miRNAs, lncRNAs, and circular RNA could lead to novel therapeutic interventions.
- Targeting ncRNAs offers a potential new approach for managing thyroid cancer.
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