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Updated: Dec 8, 2025

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
Human Saphenous Vein Histopathology 2 Years After Cyanoacrylate Closure Using the VenaSeal™ System
1Charm Vascular Clinic, Seoul, Republic of Korea.
Abstract:
There are few long-term histological studies of changes that occur after the treatment of chronic venous disease with cyanoacrylate. In the present study, a histological examination was performed in a 71-year-old man 2 years after he was treated with a VenaSeal™ system. After 2 years, most endothelial cells were destroyed; however, most of the media layer was viable. Moreover, we identified multinucleated giant cells distributed throughout the media layer but found no adventitial infiltration.
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