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Related Experiment Videos

Endogenous antioxidant defenses in neonates.

W Rosenfeld, L Concepcion

    Journal of Free Radicals in Biology & Medicine
    |January 1, 1986
    PubMed
    Summary

    Premature infants exposed to oxygen show increased superoxide dismutase (SOD) levels, an antioxidant defense. Further research is needed to determine if this SOD increase helps prevent bronchopulmonary dysplasia (BPD).

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    Area of Science:

    • Neonatal physiology
    • Biochemistry
    • Pulmonology

    Background:

    • Bronchopulmonary dysplasia (BPD) may stem from impaired antioxidant defenses.
    • Premature neonates with respiratory distress syndrome (RDS) often require prolonged oxygen therapy.
    • Evaluating antioxidant responses in neonates exposed to oxygen is crucial.

    Purpose of the Study:

    • To assess the neonates' capacity to elevate superoxide dismutase (SOD) levels in response to oxygen exposure.
    • To investigate the temporal changes in plasma SOD levels during the first week of life in premature infants.

    Main Methods:

    • Studied 9 premature neonates from birth through day 7.
    • Measured plasma superoxide dismutase (SOD) levels at multiple time points.
    • Analyzed SOD levels in neonates exposed to oxygen therapy.

    Main Results:

    • Plasma SOD levels increased significantly in neonates exposed to oxygen during the first week of life.
    • Mean SOD levels rose from 1.28 microgram/ml at birth to 2.25 micrograms/ml by day 3 (P = .003).
    • This increasing trend in SOD levels persisted through day 7.

    Conclusions:

    • Premature neonates demonstrate an enhanced antioxidant response (increased SOD) to oxygen exposure.
    • The clinical significance of this elevated SOD in preventing bronchopulmonary dysplasia (BPD) warrants further investigation.

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