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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
Published on: July 6, 2012
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Research progress in galactomannan-based nanomaterials: Synthesis and application.
Harsh Yadav1, Sabyasachi Maiti1
1Department of Pharmacy, Indira Gandhi National Tribal University, Amarkantak, Madhya Pradesh 484887, India.
International Journal of Biological Macromolecules
|September 20, 2020
Summary
Galactomannans, natural polysaccharides, are explored for drug delivery carriers like nanoparticles and hydrogels. Research highlights their use in oral vaccination, cancer targeting, and wound healing, with potential in green synthesis of nanoparticles.
Area of Science:
- Biomaterials Science
- Polymer Chemistry
- Nanotechnology
Background:
- Galactomannans are biocompatible, biodegradable polysaccharides derived from mannose and galactose.
- They are investigated for diverse drug delivery systems including nanoparticles, hydrogels, and excipients.
- Guar gum, locust bean gum, and fenugreek gum are prominent galactomannans in nanocarrier research.
Purpose of the Study:
- To review synthesis strategies for galactomannan-based nanomaterials.
- To discuss the properties and applications of these nanomaterials.
- To highlight their potential in drug delivery and other biological applications.
Main Methods:
- Fabrication of galactomannan nanomaterials using various strategies.
- Characterization of synthesized galactomannan nanomaterials.
- Evaluation of nanomaterials in applications such as drug delivery, vaccination, and heavy metal extraction.
Main Results:
- Galactomannan nanomaterials show promise in oral vaccination, insulin delivery, cancer targeting, and controlled release.
- They are utilized in wound dressings and for heavy metal extraction.
- Galactomannans serve as reducing agents for green synthesis of nanoparticles with enhanced antimicrobial and anticancer activities.
Conclusions:
- Galactomannan-based nanomaterials offer versatile platforms for advanced applications, particularly in drug delivery.
- Further research into less-studied galactomannans could unlock new biological applications.
- The review emphasizes the growing importance of galactomannans in nanotechnology and biomedical fields.
