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d-serine in physiological and pathological brain aging.

E Ploux¹, T Freret¹, J-M Billard¹

¹Normandie Univ, UNICAEN, INSERM, CYCERON, COMETE, 14000 Caen, France.

Biochimica Et Biophysica Acta. Proteins and Proteomics

|September 20, 2020

Summary

This summary is machine-generated.

d-serine, a crucial co-agonist for N-Methyl-d-Aspartate receptors (NMDAr), plays a role in cognitive aging. Research explores its potential in addressing age-related cognitive decline and Alzheimer's disease.

Keywords:

Alzheimer's disease Glutamate NMDA receptors Serine racemase Synaptic plasticity l-serine

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Area of Science:

Neuroscience
Gerontology
Pharmacology

Background:

Cognitive aging presents significant challenges to elderly quality of life.
Neuronal communication and plasticity decline with age, impacting cognitive functions.
N-Methyl-d-Aspartate receptors (NMDAr) are critical for brain plasticity and are implicated in aging.

Purpose of the Study:

To review recent findings on the role of d-serine in physiological cognitive aging.
To examine the involvement of NMDAr co-agonist d-serine in Alzheimer's disease.
To synthesize current knowledge on d-serine's contribution to cognitive function during aging.

Main Methods:

Literature review of experimental evidence on d-serine and NMDAr.
Analysis of studies investigating cognitive aging mechanisms.
Examination of research on Alzheimer's disease and NMDAr function.

Main Results:

Accumulating evidence suggests d-serine is essential for NMDAr activation.
d-serine's role in maintaining neuronal communication and plasticity during aging is highlighted.
Divergent views exist regarding d-serine's specific role in Alzheimer's disease pathology.

Conclusions:

d-serine is a key factor in the mechanisms of physiological cognitive aging.
Further research is needed to clarify the complex role of d-serine in Alzheimer's disease.
Targeting d-serine/NMDAr pathways may offer strategies for cognitive enhancement in aging.