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Anti-CASPR2 antibody associated encephalitis with anosmia and demyelinating pseudotumor: A case report
Xiang Xing1, Jinmei Li2, Siliang Chen1
1Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, Sichuan Province, PR China.
Abstract:
A 20-year-old female presented with fine motor deficits and visual field defect was admitted to our hospital. CSF tests for autoimmune encephalitis antibodies and onconeuronal antibodies were unremarkable. MRI showed unilateral lesion involving left basal ganglia, external capsule, insula, hippocampus, and amygdala, which was considered to be demyelinating pseudotumor after surgical intervention. The patient's symptoms relieved so she didn't consent to immunotherapy. Two years and a half later our patient reported sudden anosmia. Reexamination by MRI demonstrated a new lesion. We then detected anti-CASPR2 antibodies in the patient's serum and gave her immunotherapy.
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