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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Updated: Dec 8, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue mouse models for evaluating pathogenesis and countermeasures.

Rita E Chen¹, Michael S Diamond²

¹Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Current Opinion in Virology

|September 20, 2020

Summary

This summary is machine-generated.

Developing effective Dengue virus (DENV) vaccines and treatments is crucial due to widespread epidemics. This review examines the evolution and limitations of mouse models for studying DENV pathogenesis and evaluating new DENV countermeasures.

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Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse

Isolation and Quantification of Zika Virus from Multiple Organs in a Mouse

Published on: August 15, 2019

Area of Science:

Virology
Immunology
Infectious Diseases

Background:

Dengue virus (DENV) is a major global arbovirus causing significant epidemics and a wide spectrum of human illness.
The development of a safe and effective tetravalent DENV vaccine remains a high priority due to global morbidity and mortality.
Studying DENV pathogenesis and developing countermeasures has been hindered by a lack of suitable animal models that fully mimic human disease.

Purpose of the Study:

To review the utilization and limitations of mouse models in Dengue virus research.
To assess the progress in developing mouse models that recapitulate key features of human Dengue disease.
To evaluate the role of these evolving mouse models in studying DENV pathogenesis and testing therapeutics and vaccines.

Main Methods:

Literature review of studies involving mouse models for Dengue virus infection.
Analysis of the evolution and increasing success of mouse models over the past two decades.
Evaluation of the strengths and weaknesses of current mouse models for DENV research.

Main Results:

Mouse models for DENV infection have shown increasing success over the last 20 years.
Despite advancements, limitations persist in mouse models' ability to fully recapitulate human Dengue disease features.
These models are crucial for understanding DENV pathogenesis and evaluating potential vaccines and therapeutics.

Conclusions:

Evolving mouse models are valuable tools for DENV research, despite inherent limitations.
Continued refinement of mouse models is essential for advancing the study of DENV pathogenesis.
Improved animal models are critical for the successful development and deployment of effective Dengue vaccines and treatments.