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Related Concept Videos

Genomics02:02

Genomics

39.2K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

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An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing
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Single-cell genomics to understand disease pathogenesis.

Seitaro Nomura1

  • 1Department of Cardiovascular Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. senomura-cib@umin.ac.jp.

Journal of Human Genetics
|September 20, 2020
PubMed
Summary

Single-cell genomics reveals hidden molecular mechanisms of disease. This review covers recent advances and future directions in single-cell analysis for understanding complex diseases.

Area of Science:

  • Genomics
  • Molecular Biology
  • Systems Biology

Background:

  • Cells are fundamental units of biological processes.
  • Understanding cellular function requires single-cell analysis.
  • Omics technologies offer unbiased identification of molecular mechanisms.

Purpose of the Study:

  • To review recent advances in single-cell genomics.
  • To highlight the role of single-cell genomics in understanding disease pathogenesis.
  • To discuss future perspectives in the field.

Main Methods:

  • Review of current literature on single-cell genomics.
  • Analysis of studies applying single-cell genomics to disease pathogenesis.
  • Synthesis of findings to identify trends and future directions.

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Main Results:

  • Single-cell genomics has uncovered novel molecular systems involved in disease.
  • These technologies provide unprecedented resolution for studying cellular heterogeneity in disease.
  • Advances enable a deeper understanding of disease mechanisms at the molecular level.

Conclusions:

  • Single-cell genomics is a powerful tool for elucidating disease pathogenesis.
  • Continued advancements will further refine our understanding of molecular systems in health and disease.
  • Future research should focus on integrating single-cell genomics with other omics data for comprehensive insights.