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Related Experiment Video

Updated: Dec 8, 2025

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Author Spotlight: Integrating Ultrasound Imaging with Biochemical Markers for Thyroid Disease Diagnosis

Published on: February 9, 2024

Variation of Shear Wave Elastography With Preload in the Thyroid: Quantitative Validation.

Arinc Ozturk¹, Rebecca E Zubajlo², Manish Dhyani³

¹Center for Ultrasound Research & Translation, Department of Radiology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine

|September 20, 2020

Summary

Thyroid shear wave elastography (SWE) stiffness measurements vary with preload force. Standardizing transducer pressure is crucial for accurate thyroid nodule evaluation using SWE.

Keywords:

preload force quantitative ultrasound shear wave elastography thyroid nodule transducer augmentation

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Continuous Venous-Arterial Doppler Ultrasound During a Preload Challenge

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Published on: January 20, 2023

Area of Science:

Medical Imaging
Ultrasound Technology
Thyroidology

Background:

Thyroid shear wave elastography (SWE) offers advantages over biopsy for thyroid nodule evaluation.
Variability exists in SWE assessments, potentially impacting diagnostic accuracy.

Purpose of the Study:

To investigate the impact of preload force on thyroid stiffness measurements using SWE.
To determine if applied transducer pressure influences quantitative elastographic assessments.

Main Methods:

A measurement system quantified applied load during SWE.
Thyroid stiffness was measured at varying preload forces (2–10 N).
A linear mixed-effects model analyzed the preload force-stiffness association.

Main Results:

Nineteen healthy volunteers participated.
Stiffness estimates increased significantly with preload force, from 16.7 kPa at 2 N to 29.9 kPa at 10 N.
A significant nonlinear association was observed between preload force and SWE stiffness.

Conclusions:

Preload force significantly and nonlinearly affects SWE estimates of thyroid stiffness.
Standardizing preload force is essential for improving the accuracy of thyroid nodule evaluation with SWE.