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Updated: Dec 8, 2025

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
Published on: November 12, 2015
Tear film parameters before and after intracorneal ring segment implantation in keratoconic eyes
Iraklis Vastardis1, Zisis Gatzioufas2,3, Cameron McLintock2,4
1Eye Clinic, St. Johannes Hospital, Dortmund, Germany.
Purpose:
To assess signs of dry eye syndrome in keratoconic eyes following intracorneal ring segment (ICRS) implantation.
Patient And Methods:
Twenty eyes of 20 consecutive patients with keratoconus were assessed for tear film changes following ICRS implantation at 6 months postoperatively. Evaluated parameters included tear osmolarity, non-invasive tear breakup time test (NI-BUT test) and Schirmer test I and II before and after treatment.
Results:
No significant changes were found with respect to osmolarity, Schirmer I and II (p = 0.9, p < 0.64, and p < 0.91, respectively). The NITUBT was significantly lower after surgery (p = 0.04).
Conclusion:
Our results suggest that implantation of ICRS does not result in a significant change in tear film osmolarity, or tear film volume nor improves the tear film stability.

