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A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
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Can elevated concentrations of ALT and AST predict the risk of 'recurrence' of COVID-19?

L Z Chen1, Z H Lin2, J Chen3

  • 1Department of Infectious Disease, Qingdao Municipal Hospital Group, Qingdao, China.

Epidemiology and Infection
|September 21, 2020
PubMed

Insights

Elevated liver enzymes, specifically alanine aminotransferase (ALT) and aspartate aminotransferase (AST), may indicate an increased risk of coronavirus disease 2019 (COVID-19) recurrence. This finding offers insights for future prevention strategies.

Area of Science:

  • Medical Research
  • Infectious Diseases
  • Hepatology

Background:

  • The phenomenon of coronavirus disease 2019 (COVID-19) recurrence has garnered significant scholarly attention globally.
  • Understanding risk factors for COVID-19 recurrence is crucial for effective public health management.

Purpose of the Study:

  • To investigate potential clinical and biochemical markers associated with COVID-19 recurrence.
  • To identify specific indicators that may predict the likelihood of disease re-emergence in patients.

Main Methods:

  • A comparative study involving 44 COVID-19 recurrent cases and 32 control cases admitted between February and March 2020.
  • Analysis of demographic data, comorbidities, clinical symptoms, and liver enzyme concentrations (ALT and AST).

Main Results:

  • Recurrent COVID-19 cases showed significantly elevated concentrations of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) compared to controls.
  • Hypertension was the most common comorbidity in recurrent cases.
  • Fever and cough were prevalent symptoms in both groups.

Conclusions:

  • Elevated ALT and AST levels may serve as predictive markers for COVID-19 recurrence risk.
  • These findings could inform future strategies for the prevention and control of recurrent COVID-19 infections.

Keywords:
Clinical characteristiccoronavirus disease 2019predictive factorrecurrencesevere acute respiratory syndrome coronavirus-2

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