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Related Concept Videos

G-protein Coupled Receptors01:21

G-protein Coupled Receptors

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G-protein coupled receptors are ligand binding receptors that indirectly affect changes in the cell. The actual receptor is a single polypeptide that transverses the cell membrane seven times creating intracellular and extracellular loops. The extracellular loops create a ligand specific pocket which binds to neurotransmitters or hormones. The intracellular loops holds onto the G-protein.
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Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
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G Protein-coupled Receptors01:15

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G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
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Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
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GTPases and their Regulation02:14

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Guanine nucleotide-binding proteins (G-proteins), also known as GTPases, are a superfamily of proteins that regulate many cellular processes, such as cell signaling, vesicular transport, and the regulation of cell shape and motility. Mutation or dysfunction of these proteins can lead to disease. There are around 40,000 known G-proteins that can broadly be classified into two groups ‒  small G-proteins consisting of a single domain and large multi-domain G-proteins.
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Related Experiment Video

Updated: Dec 8, 2025

Analysis of Endocytic Uptake and Retrograde Transport to the Trans-Golgi Network Using Functionalized Nanobodies in Cultured Cells
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G protein-coupled receptor-associated sorting proteins: function and relevant disorders.

Min Zhang1, Li Hong Liang1, Ya Jie Lu1

  • 1Department of Medical Genetics, Nanjing Medical University, Nanjing 211166, China.

Yi Chuan = Hereditas
|September 21, 2020
PubMed
Summary

GPCR-associated sorting proteins (GASPs) regulate G protein-coupled receptor (GPCR) sorting, impacting cell signaling and disease. Understanding GASP functions offers new therapeutic strategies for neurological diseases and tumors.

Keywords:
G protein-coupled receptor-associated sorting proteins (GASPs)G protein-coupled receptors (GPCRs)diseasesignal transduction

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Background:

  • G protein-coupled receptors (GPCRs) are crucial membrane proteins involved in physiological processes.
  • GPCR-associated sorting proteins (GASPs) are key regulators of GPCR post-endocytic trafficking.
  • GASP dysfunction is linked to neurological diseases, tumors, and deafness.

Purpose of the Study:

  • To review the functions of GASPs in GPCR sorting.
  • To explore GPCR-GASP interactions and signaling pathways.
  • To highlight the therapeutic potential of targeting GASPs.

Main Methods:

  • Literature review of GASP functions.
  • Analysis of GPCR-GASP interactions.
  • Summary of GASP-related signaling pathways.

Main Results:

  • GASPs mediate GPCR degradation or recycling pathways.
  • GASPs regulate cell signaling and biological processes.
  • GASP-related pathways are implicated in transcriptional regulation.

Conclusions:

  • Understanding GASP roles in GPCR sorting is vital.
  • GASPs present potential therapeutic targets for related diseases.
  • Further research into GASP-GCPR interactions can inform treatment strategies.