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Effects of nicorandil on myocardial infarct size in patients with ST-segment elevation myocardial infarction

Xiao-Si Jiang1,2, Li-Chao Tian1,2, Zi-Chao Jiang1

  • 1Department of Cardiology, the First Medical Center of Chinese PLA General Hospital, Beijing, China.

Journal of Geriatric Cardiology : JGC
|September 21, 2020
PubMed

Insights

Perioperative intravenous nicorandil may reduce myocardial infarct size in ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI). The CHANGE study evaluates nicorandil

Area of Science:

  • Cardiology
  • Pharmacology

Background:

  • Nicorandil demonstrates cardioprotective effects.
  • Limited research exists on perioperative intravenous nicorandil for ST-segment elevation myocardial infarction (STEMI).

Purpose of the Study:

  • To evaluate the efficacy and safety of intravenous nicorandil in reducing myocardial infarct size in STEMI patients undergoing primary percutaneous coronary intervention (PCI).

Main Methods:

  • The CHANGE study is a multicenter, prospective, randomized, double-blind, parallel-controlled trial.
  • STEMI patients undergoing primary PCI in China are included.

Main Results:

  • This section is to be filled once the study is completed.

Conclusions:

  • Further evidence is needed to support myocardial protection strategies for STEMI patients with intravenous nicorandil.

Keywords:
Cardiovascular diseaseMyocardial infarct sizeNicorandilPrimary percutaneous coronary interventionST-segment elevation myocardial infarction

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