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Left ventricular diastolic dysfunction is associated with cerebral infarction in young hypertensive patients: A

Hui-Jun Wen1, Xiao-Yong Wang1

  • 1Department of Neurology, Baoji Municipal Central Hospital, Baoji, Shaanxi 721008, P.R. China.

Experimental and Therapeutic Medicine
|September 21, 2020
PubMed

Insights

Hypertension in young adults is linked to left ventricular diastolic (LVD) dysfunction. This dysfunction increases the risk of acute cerebral infarction (CI) in hypertensive young patients.

Area of Science:

  • Cardiology
  • Neurology
  • Hypertension Research

Background:

  • Hypertension is a known risk factor for acute cerebral infarction (CI) in young adults.
  • The relationship between CI and left ventricular diastolic (LVD) dysfunction in young hypertensive patients remains under-investigated.

Purpose of the Study:

  • To investigate the association between LVD dysfunction and acute CI in young hypertensive patients.

Main Methods:

  • Compared 92 young hypertensive patients with acute CI (CI group) to 98 young hypertensive patients without CI (control group).
  • Assessed blood pressure, LVD function, and performed cerebral MRI.
  • Utilized the χ² test to compare LVD function between groups.

Main Results:

  • LVD dysfunction was associated with hypertension in young patients.
  • A correlation was found between decreased LVD function and the occurrence of acute CI in this population.
  • Acute CI incidence was significantly higher in patients with decreased LVD function compared to those with normal LVD function.

Conclusions:

  • Young-onset hypertension is linked to reduced LVD function, acting as a risk factor for diastolic dysfunction.
  • LVD dysfunction may serve as an independent predictor for acute CI in young hypertensive individuals.
  • LVD assessment can aid in primary CI prevention and guide early treatment strategies for at-risk young patients.

Keywords:
cardiac morphologycerebral infarctionhypertensioninfarctionleft ventricular diastolic dysfunctionrisk factorsyoung patients

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