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Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Related Experiment Video

Updated: Dec 8, 2025

Stem Cell Transplantation Strategies for the Restoration of Cognitive Dysfunction Caused by Cranial Radiotherapy
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Stem cell therapy for Alzheimer's disease.

Xin-Yu Liu1, Lin-Po Yang1, Lan Zhao1

  • 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.

World Journal of Stem Cells
|September 21, 2020
PubMed
Summary

Stem cell therapy shows promise for Alzheimer's disease (AD) by potentially replacing lost neurons. While successful in animal models, further research is needed for clinical application in humans.

Keywords:
Alzheimer's diseaseAnimal experimentClinical trialPathogenesisStem cellTherapy

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder causing memory loss and cognitive decline.
  • Pathophysiology involves synaptic failure and protein misfolding, with significant neuron loss limiting current treatment efficacy.
  • Existing drug candidates often intervene too late in the disease progression.

Purpose of the Study:

  • To review the pathophysiology of Alzheimer's disease.
  • To explore the application prospects of stem cell therapy for AD based on cell type.
  • To assess the potential of stem cells in treating AD and related neurological disorders.

Main Methods:

  • Review of preclinical studies and recent advancements in stem cell technology.
  • Analysis of stem cell differentiation into central nervous system neurons and glial cells.
  • Examination of ongoing human clinical trials for stem cell therapies in AD.

Main Results:

  • Stem cell treatments have demonstrated success in Alzheimer's disease animal models.
  • Preclinical studies indicate promising therapeutic potential for stem cell therapy in AD.
  • Cell replacement strategies using stem cells offer a potential avenue for treating AD patients.

Conclusions:

  • Stem cell therapy holds significant potential for treating Alzheimer's disease, particularly through cell replacement.
  • Human clinical trials are underway, but further development is required for widespread clinical feasibility.
  • Understanding stem cell types and their application is crucial for advancing AD treatment.