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Stem cell therapy for Alzheimer's disease

Xin-Yu Liu1, Lin-Po Yang1, Lan Zhao1

  • 1First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.

World Journal of Stem Cells
|September 21, 2020
PubMed

Insights

Stem cell therapy shows promise for Alzheimer's disease (AD) by potentially replacing lost neurons. While successful in animal models, further research is needed for clinical application in humans.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder causing memory loss and cognitive decline.
  • Pathophysiology involves synaptic failure and protein misfolding, with significant neuron loss limiting current treatment efficacy.
  • Existing drug candidates often intervene too late in the disease progression.

Purpose of the Study:

  • To review the pathophysiology of Alzheimer's disease.
  • To explore the application prospects of stem cell therapy for AD based on cell type.
  • To assess the potential of stem cells in treating AD and related neurological disorders.

Main Methods:

  • Review of preclinical studies and recent advancements in stem cell technology.
  • Analysis of stem cell differentiation into central nervous system neurons and glial cells.
  • Examination of ongoing human clinical trials for stem cell therapies in AD.

Main Results:

  • Stem cell treatments have demonstrated success in Alzheimer's disease animal models.
  • Preclinical studies indicate promising therapeutic potential for stem cell therapy in AD.
  • Cell replacement strategies using stem cells offer a potential avenue for treating AD patients.

Conclusions:

  • Stem cell therapy holds significant potential for treating Alzheimer's disease, particularly through cell replacement.
  • Human clinical trials are underway, but further development is required for widespread clinical feasibility.
  • Understanding stem cell types and their application is crucial for advancing AD treatment.
Keywords:
Alzheimer's diseaseAnimal experimentClinical trialPathogenesisStem cellTherapy

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