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Related Concept Videos

Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Bone Remodeling01:40

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In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Related Experiment Video

Updated: Dec 8, 2025

Author Spotlight: An Economic and Efficient Method for Quantitative Evaluation of Bone Microarchitecture in a Murine Osteoporosis Model
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Obesity and Bone.

Joseph Proietto1

  • 1Department of Medicine, Austin Health, University of Melbourne, Repatriation Hospital, Heidelberg Heights 3081, Victoria, Australia.

F1000Research
|September 21, 2020
PubMed
Summary
This summary is machine-generated.

Obesity impacts bone health, offering fracture protection in some areas but increasing risk in others due to complex bone fragility mechanisms. Bone cells also influence body weight regulation.

Keywords:
Body weight regulationBone marrowFTO geneInflammationOsteoblastOsteoporosisosteoclastosteocyte

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Area of Science:

  • Bone biology
  • Metabolic disorders
  • Skeletal health

Background:

  • Obesity and osteoporosis are prevalent conditions linked to significant morbidity and mortality.
  • The relationship between obesity and bone health is complex, influencing fracture risk.
  • Factors like bone quality, fall risk, and surrounding tissue padding contribute to fracture outcomes.

Purpose of the Study:

  • To explore the multifaceted relationship between obesity and bone health.
  • To elucidate mechanisms by which obesity affects bone fragility and fracture risk.
  • To investigate the bidirectional communication between bone cells and body weight regulation.

Main Methods:

  • Review of existing literature on obesity, osteoporosis, and bone biology.
  • Analysis of factors influencing fracture risk in obese individuals.
  • Examination of cellular and molecular mechanisms linking obesity to bone fragility.
  • Exploration of emerging evidence on osteocyte function in weight regulation.

Main Results:

  • Obesity paradoxically protects against fractures at certain sites while increasing risk at others.
  • Obesity-induced bone fragility arises from increased marrow fat, inflammatory cytokines, FTO gene mutations, and osteoblast senescence.
  • Bone cells, specifically osteocytes, can act as regulators of body weight.

Conclusions:

  • The interplay between obesity and bone is complex and bidirectional.
  • Understanding these mechanisms is crucial for managing fracture risk in obese populations.
  • Osteocytes play a role in energy homeostasis, suggesting novel therapeutic targets.