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Primary acral amelanotic melanoma: A rare case report
Jiaojiao Zhang1,2, Huizhi Yang3, Jiaxi Lin4
1Dermatology Hospital, Southern Medical University, Guangzhou, Guangdong 510095, P.R. China.
Molecular and Clinical Oncology
|September 21, 2020
Summary
This study presents a rare case of primary acral amelanotic malignant melanoma (AMM), an aggressive foot tumor. Histopathology and immunohistochemistry confirmed the diagnosis in a 61-year-old man.
Area of Science:
- Oncology
- Dermatopathology
Background:
- Acral malignant melanoma (AMM) is a rare subtype of melanoma.
- Amelanotic variants lack pigment, posing diagnostic challenges.
Purpose of the Study:
- To report a rare case of primary acral amelanotic malignant melanoma (AMM).
- To highlight diagnostic features and confirm findings through histopathology and immunohistochemistry.
Main Methods:
- Case presentation of a 61-year-old male with a foot tumor.
- Histopathological examination of biopsy tissue.
- Immunohistochemical staining for tumor markers (Ki67, Melan-A, HMB45, CD20, CK7, CK5/6).
Main Results:
- A 61-year-old man presented with an aggressive, non-pigmented tumor on his left foot sole.
- Biopsy showed ulceration, tumor cells in the dermis, and multinucleated giant cells.
- Immunohistochemistry confirmed AMM with positive Ki67, Melan-A, and HMB45, and negative CD20, CK7, CK5/6.
Conclusions:
- Primary acral amelanotic malignant melanoma is a rare entity.
- Histopathology and immunohistochemistry are crucial for accurate diagnosis of amelanotic melanoma.
- This case underscores the importance of considering AMM in non-pigmented acral lesions.
