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Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Molecular differences across invasive lung adenocarcinoma morphological subgroups.

Bo Ci¹, Donghan M Yang¹, Ling Cai^1,2,3

¹Quantitative Biomedical Research Center, Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA.

Translational Lung Cancer Research

|September 21, 2020

Summary

Molecular differences in lung adenocarcinoma (ADC) subtypes are linked to gene expression, not mutations. FOXM1 and PD-L1 protein levels correlate with ADC morphology and patient survival, suggesting targeted therapies.

Keywords:

FOXM1 Lung adenocarcinoma (lung ADC)differentiation morphological subgroup

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Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

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Published on: March 17, 2020

Area of Science:

Oncology
Genomics
Translational Research

Background:

Lung adenocarcinomas (ADCs) exhibit diverse morphologies, classified into five subtypes.
Morphological classification impacts patient prognosis and chemotherapy response.
Molecular drivers of ADC morphological heterogeneity are largely unknown.

Purpose of the Study:

Investigate molecular distinctions across invasive lung ADC morphological subgroups.
Identify molecular mechanisms underlying ADC subtype differences.

Main Methods:

Utilized The Cancer Genome Atlas (TCGA) lung adenocarcinoma (LUAD) cohort for molecular profiling.
Analyzed gene expression (mRNA, protein), gene mutations, and copy number alterations (CNA).

Main Results:

Significant associations found between ADC morphology and mRNA/protein expression, but not gene mutations or CNA.
FOXM1 gene expression, inversely correlated with survival, plays a role in morphological variation.
PD-L1 protein abundance correlates with ADC subgroup malignancy.
Findings validated in an independent cohort.

Conclusions:

Reveals molecular differences among lung ADC morphological subgroups.
Highlights potential for developing targeted therapies specific to ADC subtypes.