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Significant Association between Microrna Gene Polymorphisms and Type 2 Diabetes Mellitus Susceptibility in Asian

Zhifang Deng1,2, Wenqi Gao3,4, Wei Luo1

  • 1Department of Pharmacy, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People's Hospital, Yichang, 443000, China.

Iranian Journal of Public Health
|September 21, 2020
PubMed
Abstract

Insights

MicroRNA gene variations, specifically microRNA146a rs2910164 (G allele) and microRNA124a rs531564 (C allele), may protect against type 2 diabetes mellitus (T2DM) in Asian populations. These findings clarify previous inconsistent results regarding T2DM susceptibility.

Area of Science:

  • Genetics
  • Molecular Biology
  • Endocrinology

Background:

  • MicroRNA gene polymorphisms are implicated in type 2 diabetes mellitus (T2DM) susceptibility.
  • Previous studies on this association have yielded inconsistent and unclear results.
  • A comprehensive meta-analysis is needed to clarify these relationships.

Purpose of the Study:

  • To precisely investigate the associations between specific microRNA gene polymorphisms and T2DM risk.
  • To evaluate the role of microRNA146a rs2910164 (G>C) and microRNA124a rs531564 (C>G) in T2DM susceptibility within the Asian population.

Main Methods:

  • A systematic literature search was conducted across PubMed, Embase, CNKI, and Wan-fang databases.
  • Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the associations.
  • The meta-analysis included studies published in English and Chinese.

Main Results:

  • Four studies were included in the meta-analysis.
  • Significant associations were observed between T2DM susceptibility and the studied single nucleotide polymorphisms (SNPs).
  • The G allele of microRNA146a rs2910164 and the C allele of microRNA124a rs531564 were associated with a remarkably reduced risk of T2DM.

Conclusions:

  • The G allele of microRNA146a rs2910164 and the C allele of microRNA124a rs531564 may act as protective factors in the pathogenesis of T2DM.
  • These specific microRNA polymorphisms show potential as biomarkers for T2DM risk in the Asian population.
Keywords:
Gene polymorphismSusceptibilityType 2 diabetes mellitusmicroRNAs

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