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Updated: Dec 8, 2025

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
Published on: August 30, 2020
Hemorrhagic stroke and COVID-19 infection: Coincidence or causality?
Pedro Fraiman1, Mariana Freire2, Manuel Moreira-Neto3,4
1Division of Neurology, Hospital Universitário Onofre Lopes, Universidade Federal do Rio Grande do Norte (UFRN), Av. Nilo Peçanha, S/N, Petropolis, Natal, RN 59012-300, Brazil.
Abstract:
Amyloid Protein Precursor gene duplication is a rare cause of early-onset Alzheimer's disease that can be associated with Cerebral Amyloid Angiopathy. This condition predisposes cerebrovascular events, specifically, intracerebral hemorrhagic stroke. This report describes a case of first-time intracerebral hemorrhage in a patient with APP gene duplication during SARS-CoV-2 infection, a typically pro-thrombotic and pro-inflammatory condition, as a possible trigger for this condition.
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