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Related Experiment Video

Updated: Dec 8, 2025

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
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COVID-19-associated sleep disorders: A case report.

Abeer A Tony1, Effat Ae Tony2, Shazly B Ali3

  • 1Department of Neuropsychiatry, Faculty of Medicine, Aswan University, Egypt.

Neurobiology of Sleep and Circadian Rhythms
|September 21, 2020
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Summary

This case study reports a patient with COVID-19 experiencing insomnia and restless leg syndrome. These sleep disturbances highlight a potential link between SARS-CoV-2 infection and neuropsychiatric symptoms.

Keywords:
COVID-19Sleep disorders

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Area of Science:

  • Neurology
  • Infectious Diseases
  • Sleep Medicine

Background:

  • The COVID-19 pandemic has seen a rise in reported neurological and psychiatric symptoms.
  • Sleep disturbances are increasingly recognized as potential sequelae of viral infections.

Purpose of the Study:

  • To report a rare case of a patient with SARS-CoV-2 infection presenting with significant sleep disorders.
  • To investigate the association between COVID-19 and neuropsychiatric manifestations, specifically insomnia and restless leg syndrome.

Main Methods:

  • A case report detailing a 49-year-old female patient diagnosed with COVID-19.
  • Data collection involved reviewing medical records from Al-Raghy Isolation Hospital.

Main Results:

  • The patient presented with insomnia and restless leg syndrome alongside typical COVID-19 symptoms including fever, cough, and respiratory distress.
  • Nasopharyngeal swab confirmed SARS-CoV-2 infection.
  • The patient recovered neurologically and respiratorily after 10 days of treatment.

Conclusions:

  • This case highlights the rare occurrence of restless leg syndrome and insomnia in COVID-19 patients.
  • Further research is needed to characterize the spectrum of sleep disorders in COVID-19 and understand the potential link with neuropsychiatric illness.