Related Experiment Video
Updated: Dec 8, 2025

Multimodality Diagnosis of Mesenteric Ischemia
Published on: July 21, 2023
Meckel's diverticulum with polypoid hyperplasia of ectopic gastric mucosa diagnosed by double-balloon enteroscopy and
Jun Yang1, Dan Tian1, Lihua Wu1
1Department of Nuclear Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, P.R. China.
Abstract:
Meckel's diverticulum (MD) is a relatively common true congenital diverticulum on the ileum. Bleeding caused by polypoid hyperplasia of ectopic gastric mucosa in MD is rare. A 14-year-old Chinese boy presented with intermittent melena and haematochezia for 1 month. Laboratory data showed normocytic anaemia. Gastroscopic findings were normal. The patient underwent exploratory laparotomy without bowel preparation on day 2 because of sudden haematochezia and decreased haemoglobin. Intraoperative colonoscopy revealed inflammatory changes in the terminal ileal mucosa with diffuse haemorrhage. Melena with decreased haemoglobin recurred 20 days after the first operation. Computed tomography (CT) and angiography revealed a tubular lesion that was localised in the right lower abdominal quadrant. Single-photon emission computed tomography/computed tomography (SPECT/CT) fusion imaging with 99m-technetium pertechnetate confirmed moderately increased uptake in the distal ileum. Retrograde double-balloon enteroscopy (DBE) showed a diverticulum with prominent mucosal polypoid hyperplasia at an insertion depth of 100 cm from the anastomotic stoma. Diverticulectomy and end-to-end anastomosis were performed, and MD was confirmed by a histopathological examination. The patient's postoperative recovery was uneventful during the 2-month follow-up. MD with polypoid hyperplasia of ectopic gastric mucosa is rare. Complementary use of DBE and SPECT/CT can accurately diagnose MD by providing anatomical and functional information.
Insights
A rare case of Meckel's diverticulum (MD) bleeding due to ectopic gastric mucosa was diagnosed. Combined double-balloon enteroscopy and SPECT/CT accurately identified the MD, leading to successful surgical treatment.
Area of Science:
- Gastroenterology
- Pediatric Surgery
- Diagnostic Imaging
Background:
- Meckel's diverticulum (MD) is a common congenital ileal anomaly.
- Bleeding from MD caused by ectopic gastric mucosa with polypoid hyperplasia is a rare complication.
- This case highlights a diagnostic challenge in a young patient with recurrent gastrointestinal bleeding.
Purpose of the Study:
- To report a rare case of Meckel's diverticulum presenting with significant gastrointestinal bleeding.
- To emphasize the diagnostic utility of advanced imaging techniques in identifying the source of obscure bleeding.
- To demonstrate the successful management of this rare condition.
Main Methods:
- A 14-year-old boy with intermittent melena and anemia underwent initial investigations including gastroscopy and exploratory laparotomy with intraoperative colonoscopy.
- Computed tomography (CT), angiography, and SPECT/CT with 99m-technetium pertechnetate were utilized for localization.
- Retrograde double-balloon enteroscopy (DBE) was performed for detailed visualization and diagnosis.
Main Results:
- Initial investigations were inconclusive, but recurrent bleeding prompted advanced imaging.
- SPECT/CT confirmed increased radiotracer uptake in the distal ileum.
- DBE revealed a Meckel's diverticulum with prominent mucosal polypoid hyperplasia, confirming the diagnosis.
- Surgical resection (diverticulectomy) resulted in an uneventful recovery.
Conclusions:
- Meckel's diverticulum with polypoid hyperplasia of ectopic gastric mucosa is an uncommon cause of gastrointestinal bleeding.
- The complementary use of double-balloon enteroscopy and SPECT/CT provides accurate anatomical and functional information for diagnosing such rare conditions.
- This multimodal diagnostic approach is crucial for effective management and improved patient outcomes.
Related Concept Videos
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Barrett Esophagus-I: Introduction
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and...
Endoscopic Procedures I: Esophagogastroduodenoscopy
During an EGD, the endoscope can be used to:
Endoscopic Procedures III: Video Capsule Endoscopy

