Automated detection of diabetic retinopathy in fundus images using fused features

Diabetic retinopathy (DR) is one of the severe eye conditions due to diabetes complication which can lead to vision loss if left untreated. In this paper, a computationally simple, yet very effective, DR detection method is proposed. First, a segmentation independent two-stage preprocessing based technique is proposed which can effectively extract DR pathognomonic signs; both bright and red lesions, and blood vessels from the eye fundus image. Then, the performance of Local Binary Patterns (LBP), Local Ternary Patterns (LTP), Dense Scale-Invariant Feature Transform (DSIFT) and Histogram of Oriented Gradients (HOG) as a feature descriptor for fundus images, is thoroughly analyzed. SVM kernel-based classifiers are trained and tested, using a 5-fold cross-validation scheme, on both newly acquired fundus image database from the local hospital and combined database created from the open-sourced available databases. The classification accuracy of 96.6% with 0.964 sensitivity and 0.969 specificity is achieved using a Cubic SVM classifier with LBP and LTP fused features for the local database. More importantly, in out-of-sample testing on the combined database, the model gives an accuracy of 95.21% with a sensitivity of 0.970 and specificity of 0.932. This indicates the proposed model is very well-fitted and generalized which is further corroborated by the presented train-test curves.