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An Immature Murine Model of Reversible Unilateral Ureteral Obstruction
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[PROTEINURIA IN PATIENTS WITH ACUTE URINARY TRACT OBSTRUCTION].
Dvorah Sara Shapiro1, Irina Alexandrovich1, Nurit Algur2
1Department of Geriatrics, Shaare Zedek Medical Center, Jerusalem, Israel.
Harefuah
|September 21, 2020
Summary
Urinary tract obstructions (UTO) cause significant proteinuria in hospitalized patients. This proteinuria does not resolve early after obstruction relief, suggesting potential long-term implications.
Area of Science:
- Nephrology
- Urology
- Internal Medicine
Background:
- Urinary tract obstructions (UTO) are known to cause tubular injury.
- The potential for UTO to induce transient proteinuria requires further investigation.
Purpose of the Study:
- To compare proteinuria incidence and severity in patients with UTO versus catheterized controls.
- To assess early resolution of proteinuria after UTO relief.
Main Methods:
- Prospective, matched case-control study of 100 patients (50 UTO, 50 controls).
- Quantified proteinuria using consecutive 24-hour urine collections.
- Compared incidence, severity, and quantitative changes between groups.
Main Results:
- All patients with UTO and 94% of controls exhibited abnormal proteinuria.
- No significant difference in proteinuria degree or changes during hospitalization between groups.
- Proteinuria did not significantly change within a week of follow-up in either group.
Conclusions:
- High incidence of significant proteinuria observed in hospitalized patients, with or without UTO.
- Early post-relief proteinuria in UTO patients does not resolve.
- Longer follow-up is necessary to determine long-term resolution and prognostic significance of proteinuria.
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