Monoaminergic fibers form conventional synapses in the cerebral cortex

The morphological characteristics of the monoaminergic axon-terminals in the mammalian cerebral cortex have been the subject of controversy in recent years. Systematic analysis of serial ultrathin sections, immunocytochemically stained with antibodies against noradrenaline and serotonin, has shown that nearly all stained terminals form synapses characterized by specialized junctional appositions. These results suggest that, contrary to the widely held view, monoamines in the cortex are released at specialized junctions.