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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

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Published on: November 5, 2019

Case 286.

Jason Chiang¹, Frank Hebroni¹, Arash Bedayat¹

¹From the Department of Radiology, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 1638, Los Angeles, CA 90095.

|September 21, 2020

Summary

This summary is machine-generated.

A 70-year-old man with metastatic melanoma experienced new lung and mediastinal lesions after starting nivolumab (anti-PD-1) therapy. His subcutaneous disease remained stable, indicating a complex response to immunotherapy.

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Area of Science:

Oncology
Immunotherapy
Radiology

Background:

A 70-year-old man presented with biopsy-proven melanoma and subsequent development of subcutaneous satellite lesions indicating metastatic disease.
The patient initiated treatment with nivolumab, an immune checkpoint inhibitor targeting programmed cell death 1 (PD-1), for advanced metastatic melanoma.

Purpose of the Study:

To report imaging findings in a patient with metastatic melanoma treated with nivolumab.
To describe the evolution of metastatic disease during PD-1 inhibitor therapy.

Main Methods:

Serial positron emission tomography/computed tomography (PET/CT) and chest CT scans were utilized for disease monitoring.
The patient received nivolumab as a first-line treatment for advanced metastatic melanoma.

Main Results:

Initial scans showed subcutaneous metastatic disease but no evidence of visceral or lymph node involvement.
Five months after starting nivolumab, follow-up chest CT revealed new metastatic lesions in the mediastinum and bilateral lungs.
The subcutaneous metastatic disease remained stable, and the patient remained asymptomatic throughout the initial treatment period.

Conclusions:

Nivolumab treatment in this patient with advanced melanoma led to the emergence of new metastatic sites in the lungs and mediastinum.
This case highlights the potential for varied responses to PD-1 inhibitors, including new lesion formation alongside stable subcutaneous disease.