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Related Concept Videos

Aging01:26

Aging

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Exercise and Cardiac Output01:17

Exercise and Cardiac Output

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Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
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Correlation between ECG and Cardiac Cycle01:25

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The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
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Electrophysiology of Normal Cardiac Rhythm01:19

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The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
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Factors Influencing Heart Rate01:30

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The heart rate, or pulse rate, is a vital indicator of cardiovascular health. It reflects the number of times the heart beats per minute. Various physiological and environmental factors influence heart rate, increasing or decreasing cardiac output. Understanding these factors is crucial for assessing heart function and identifying potential health issues.
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Getting to Compliance in Forced Exercise in Rodents: A Critical Standard to Evaluate Exercise Impact in Aging-related Disorders and Disease
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Aging with rhythmicity. Is it possible? Physical exercise as a pacemaker.

Alexandre Abilio de Souza Teixeira1, Fábio Santos Lira2, José Cesar Rosa-Neto1

  • 1Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.

Life Sciences
|September 21, 2020
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Summary

Aging disrupts circadian rhythms, increasing inflammation and accelerating aging. Regular physical exercise can restore rhythmicity, promoting healthier aging and longevity by regulating inflammatory processes.

Keywords:
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Area of Science:

  • Gerontology
  • Chronobiology
  • Immunology

Background:

  • Aging is linked to declining physiological functions, including metabolism and immunity.
  • Circadian rhythm disruptions are associated with chronic diseases and accelerated aging.
  • Inflammaging, a chronic low-grade inflammation with age, predicts age-related disease susceptibility.

Purpose of the Study:

  • To explore the intricate relationships between aging, circadian rhythms, and inflammaging.
  • To investigate how aging impacts circadian clock function and immune system regulation.
  • To examine the role of physical exercise in modulating circadian rhythms and mitigating age-related inflammation.

Main Methods:

  • This review synthesizes current research on aging, circadian biology, and inflammation.
  • It analyzes the molecular mechanisms linking clock genes, immune responses, and age-related pathologies.
  • The review discusses the impact of lifestyle factors like exercise on circadian rhythmicity and inflammaging.

Main Results:

  • Aging is characterized by circadian rhythm disturbances that exacerbate inflammaging.
  • Pro-inflammatory cytokines, influenced by circadian disruption, contribute to age-related muscle loss.
  • Sedentary lifestyles and poor nutrition further disrupt circadian rhythms, promoting inflammation.

Conclusions:

  • Maintaining circadian rhythmicity is crucial for healthy aging and immune function.
  • Physical exercise emerges as a key strategy to regulate circadian rhythms and combat inflammaging.
  • Lifelong exercise promotes longevity and improves quality of life by decelerating aging processes.