Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.2K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.2K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

26.3K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
26.3K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

5.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
5.1K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.0K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Glucose concentration of neuronal media formulations influences PINK1-dependent mitophagy in human iNeurons.

Autophagy reports·2026
Same author

Methodology for human-induced pluripotent stem cell-derived excitatory and inhibitory neuron coculture with astrocytes for Alzheimer's disease modelling.

Brain communications·2026
Same author

The complete genome of the KOLF2.1J reference iPSC line.

bioRxiv : the preprint server for biology·2026
Same author

Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer's disease.

Brain communications·2026
Same author

Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits.

Neuron·2026
Same author

Dual targeting of the UPS and autophagy as a novel therapy for neurodegenerative proteinopathies.

Frontiers in cellular neuroscience·2026

Related Experiment Video

Updated: Dec 8, 2025

Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring
09:34

Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring

Published on: August 6, 2020

7.6K

Modelling frontotemporal dementia using patient-derived induced pluripotent stem cells.

Georgie Lines1, Jackie M Casey1, Elisavet Preza1

  • 1Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, 1 Wakefield Street, London WC1N 1PJ, UK.

Molecular and Cellular Neurosciences
|September 21, 2020
PubMed
Summary

Frontotemporal dementia (FTD) research is advancing with patient-specific induced pluripotent stem cells (iPSCs). These models help study FTD pathologies in relevant human cells, accelerating therapeutic development.

Keywords:
C9ORF72FTDProgranulinTDP-43TauiPSC

More Related Videos

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

829
A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
09:30

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

18.8K

Related Experiment Videos

Last Updated: Dec 8, 2025

Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring
09:34

Automated Production of Human Induced Pluripotent Stem Cell-Derived Cortical and Dopaminergic Neurons with Integrated Live-Cell Monitoring

Published on: August 6, 2020

7.6K
In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells
06:38

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Published on: March 7, 2025

829
A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases
09:30

A Guide to Generating and Using hiPSC Derived NPCs for the Study of Neurological Diseases

Published on: February 21, 2015

18.8K

Area of Science:

  • Neuroscience
  • Genetics
  • Stem Cell Biology

Background:

  • Frontotemporal dementia (FTD) is a heterogeneous neurodegenerative disorder often affecting individuals under 65.
  • Genetic causes include MAPT, GRN, and C9ORF72 mutations, leading to abnormal protein aggregates like tau and TDP-43.
  • Currently, no disease-modifying therapies exist for FTD, highlighting the need for effective in vitro models.

Purpose of the Study:

  • To review the progress and potential of using induced pluripotent stem cells (iPSCs) to model genetic Frontotemporal dementia (FTD).
  • To explore the advantages and disadvantages of iPSC-based FTD models.
  • To discuss future directions for developing novel therapeutics for FTD.

Main Methods:

  • Generation of patient-specific induced pluripotent stem cells (iPSCs) from somatic cells.
  • Differentiation of iPSCs into relevant cell types, including neurons, astrocytes, and microglia.
  • Utilizing these iPSC-derived cells to create in vitro models of genetic FTD.

Main Results:

  • iPSC technology enables the creation of in vitro models of genetic FTD in human cell types.
  • These models recapitulate disease-specific pathologies, offering a platform for studying disease mechanisms.
  • Patient-specific iPSC models provide insights into FTD in cell types difficult to access in living patients.

Conclusions:

  • Induced pluripotent stem cells (iPSCs) offer a powerful tool for modeling Frontotemporal dementia (FTD) in patient-relevant cell types.
  • iPSC-based models are crucial for understanding FTD pathogenesis and for the preclinical testing of new therapies.
  • Further research into iPSC technology holds significant promise for advancing FTD therapeutics.