Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Cytotoxic antibodies in multiple sclerosis].

L Rumbach, M M Tongio, S Mayer

    Pathologie-Biologie
    |March 1, 1987
    PubMed
    Summary

    Multiple sclerosis (MS) patients exhibit unique cold cytotoxic activities in their serum, potentially involving various cytotoxic antibodies. These activities, detected against lymphocytes and monocytes, were notably present in MS patients but not in healthy controls.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Unexpected combination of inherited chorea-acanthocytosis with MDR3 (ABCB4) defect mimicking Wilson's disease.

    Clinical genetics·2010
    Same author

    Foreign accent syndrome as a first sign of multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2009
    Same author

    Kennedy's Disease Initially Manifesting as an Endocrine Disorder.

    Journal of clinical neuromuscular disease·2008
    Same author

    [Recurrent ischemic strokes revealing Lyme meningovascularitis].

    Revue neurologique·2008
    Same author

    [Reperfusion syndrome with cerebral vasogenic edema after carotid artery endarterectomy].

    Revue neurologique·2007
    Same author

    Myopathy with tubular aggregates and gyrate atrophy of the choroid and retina due to hyperornithinaemia.

    Journal of neurology, neurosurgery, and psychiatry·2006

    Area of Science:

    • Immunology
    • Neurology

    Context:

    • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
    • The role of autoantibodies and cytotoxic mechanisms in MS pathogenesis remains incompletely understood.

    Purpose:

    • To investigate the presence and characteristics of serum cold cytotoxic activities in multiple sclerosis (MS) patients.
    • To compare these activities with those found in non-MS patients and healthy controls.

    Summary:

    • Serum cold cytotoxic activities against lymphocytes, B lymphocytes, and monocytes were detected in a significant proportion of MS patients at 15°C and 37°C.
    • Cytotoxic activity was also observed in cerebrospinal fluid (CSF) of MS patients, particularly lysis of monocytes at 37°C without complement.
    • Positive tests with autologous cells (autocells) were found in some MS patients, suggesting potential auto-reactivity.

    Related Experiment Videos

    Impact:

    • The findings suggest the presence of diverse cytotoxic antibodies in MS patients, although their specific role in disease progression is yet to be determined.
    • These antibodies may influence specific lymphocyte subsets, warranting further investigation into their pathogenetic significance in MS.