Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cleavage and Blastulation01:33

Cleavage and Blastulation

49.2K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
49.2K
Cellular Differentiation00:57

Cellular Differentiation

4.7K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
4.7K
Determination01:51

Determination

20.4K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
20.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tofacitinib, the First Oral Janus Kinase Inhibitor Approved for Adult Ulcerative Colitis.

Journal of pharmacy practice·2020
Same author

Keratins are asymmetrically inherited fate determinants in the mammalian embryo.

Nature·2020
Same author

Quantitative analysis of differentially expressed proteins in psoriasis vulgaris using tandem mass tags and parallel reaction monitoring.

Clinical proteomics·2020
Same author

MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133.

International journal of biological sciences·2020
Same author

Suicidal Ideation in Newly-Diagnosed Chinese Cancer Patients.

Frontiers in psychiatry·2020
Same author

Low Normal TSH Levels and Thyroid Autoimmunity are Associated with an Increased Risk of Osteoporosis in Euthyroid Postmenopausal Women.

Endocrine, metabolic & immune disorders drug targets·2020

Related Experiment Video

Updated: Dec 8, 2025

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
08:21

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

Published on: March 16, 2017

9.0K

Progress in deciphering trophoblast cell differentiation during human placentation.

Zhenyu Xiao1, Long Yan2, Xiaoyan Liang3

  • 1State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China; Innovation Academy for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing, 100101, China.

Current Opinion in Cell Biology
|September 21, 2020
PubMed
Summary

Proper placental development, driven by trophoblast cell differentiation, is crucial for a healthy pregnancy. Recent advances in stem cell culture and single-cell analysis are illuminating the mechanisms behind this process and its role in pregnancy complications.

Keywords:
InterferonOrganoidsPlacentaSingle-cell multi-omicsSyncytializationTrophoblast

More Related Videos

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

6.5K
Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay
10:28

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay

Published on: January 8, 2012

24.6K

Related Experiment Videos

Last Updated: Dec 8, 2025

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
08:21

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells

Published on: March 16, 2017

9.0K
Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos
08:50

Single Cell Collection of Trophoblast Cells in Peri-implantation Stage Human Embryos

Published on: June 12, 2020

6.5K
Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay
10:28

Isolation of Primary Mouse Trophoblast Cells and Trophoblast Invasion Assay

Published on: January 8, 2012

24.6K

Area of Science:

  • Reproductive biology
  • Developmental biology
  • Genetics

Background:

  • Gestational well-being depends on embryonic and placental development.
  • Trophoblast cells are key placental building blocks.
  • Abnormal trophoblast differentiation causes pregnancy complications, but mechanisms are unclear.

Purpose of the Study:

  • To review recent literature (2017-2019) on human trophoblast differentiation.
  • To highlight advancements in understanding trophoblast differentiation mechanisms.
  • To discuss the role of trophoblast differentiation in pregnancy and its complications.

Main Methods:

  • Literature review focusing on 2017-2019 publications.
  • Analysis of new tools like human trophoblast stem cell cultures and 3D placental organoids.
  • Incorporation of single-cell multi-omics insights.

Main Results:

  • Recent studies have identified key proteins and regulators of trophoblast differentiation.
  • Novel technologies have provided significant insights into placental development.
  • Understanding of trophoblast differentiation's role in pregnancy complications has advanced.

Conclusions:

  • Human trophoblast stem cell cultures, 3D organoids, and single-cell multi-omics are revolutionizing placental research.
  • Continued research is vital for addressing challenges in human placental development and disease.
  • Elucidating trophoblast differentiation mechanisms is critical for managing pregnancy complications.