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[Serum zinc and copper in hypercholesterolemia].

Y Thuillier-Juteau, M C Jaudon, J P Clavel

    Pathologie-Biologie
    |April 1, 1987
    PubMed
    Summary

    This study found that hypercholesterolemic patients have elevated serum copper and decreased serum zinc, impacting lipid metabolism. These trace element levels significantly correlate with HDL cholesterol, suggesting a role in cardiovascular disease risk.

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    Area of Science:

    • Biochemistry
    • Cardiovascular Medicine
    • Nutritional Science

    Context:

    • Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide.
    • Altered lipid metabolism is a key factor in CVD development.
    • The role of trace elements like copper and zinc in lipid metabolism and CVD etiology is under investigation, with prior studies yielding inconsistent results.

    Purpose:

    • To investigate the correlation between serum copper and zinc levels and lipid profiles in hypercholesterolemic patients.
    • To explore the potential role of serum zinc/copper ratio as a risk factor in cardiovascular disease.

    Summary:

    • This study analyzed serum copper, zinc, and lipid levels in 67 hypercholesterolemic patients.
    • Results indicated elevated serum copper and decreased serum zinc and zinc/copper ratio in patients with cholesterol > 7.7 mmol/l.

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  • Significant correlations were observed between serum zinc, copper, and the zinc/copper ratio with HDL cholesterol levels.

    • Impact:

    • Findings suggest that serum copper and zinc levels, and their ratio, are significantly associated with HDL cholesterol in hypercholesterolemic individuals.
    • This research may contribute to understanding the link between trace element imbalances and cardiovascular disease risk.
    • Further research could explore therapeutic interventions targeting copper and zinc metabolism for managing hypercholesterolemia and reducing CVD risk.