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The Age Distribution among Children Seeking Medical Treatment for Precocious Puberty in Taiwan
Pen-Hua Su1,2, Jing-Yang Huang3,4, Cho-Shun Li5
1School of Medicine, Chung Shan Medical University, Taichung 41354, Taiwan.
Insights
The number of children diagnosed with precocious puberty (PP) significantly increased between 2000 and 2013. This trend highlights the need for increased awareness of environmental factors and early medical intervention for PP.
Area of Science:
- Pediatric Endocrinology
- Public Health
- Epidemiology
Background:
- Precocious puberty (PP) presents significant physiological and psychological challenges for affected children.
- Understanding trends in seeking medical care for PP is crucial for resource allocation and patient management.
Purpose of the Study:
- To investigate the trends in prevalence and incidence of precocious puberty (PP) in children.
- To analyze the changes in seeking medical care for PP over time.
Main Methods:
- Utilized the Taiwan National Health Insurance Research Dataset (NHIRD) from 2000-2013.
- Estimated prevalence and incidence of PP (ICD-9 code: 259.1) in boys (0-11 years) and girls (0-10 years).
- Employed join-point regression to determine trends and compared management proportions within one year of diagnosis between different periods.
Main Results:
- Prevalence of PP significantly increased from 2000 to 2013 for both boys and girls.
- Incidence rates also showed a marked rise, with girls consistently having higher rates than boys.
- The frequency of pediatric endocrinology outpatient visits for PP increased substantially across both genders during the study period.
Conclusions:
- The study observed a significant increase in the frequency of medical visits for precocious puberty (PP) in both genders from 2000 to 2013.
- Emphasizes the importance of monitoring children's health, environmental exposures (hormones, diet), and enhancing parental education regarding PP.
- Recommends further research into PP surveillance and improved educational strategies to optimize medical resource utilization and timely care.
Objective:
Children with precocious puberty (PP) may have increased physiological and psychological problems. In this study, we aimed to explore the trend of parents seeking medical care for their children with precocious puberty.
Methods:
The Taiwan National Health Insurance Research Dataset (NHIRD) was used to estimate the prevalence (2000-2013) and incidence (2002-2013) of PP (ICD-9 code: 259.1) among boys aged 0-11 years and girls aged 0-10 years. The proportions of PP management within 1 year from the date of first diagnosis were also compared between two periods (2002-2007 and 2008-2012). The trends of PP prevalence or incidence were determined by join-point regression.
Results:
In 2000, 309 boys and 2706 girls had at least one visit for PP, the crude prevalence rates (per 10,000 persons) were 0.99 (95% confidence interval, 95% CI 0.87-1.14) and 13.56 (95% CI 13.01-14.13) in boys and girls, respectively. In 2013, the crude prevalence rates increased to 7.01 (95% CI 6.56-7.84) and 110.95 (95% CI 108.97-112.96) in boys and girls, respectively. A total of 2584 girls and 207 boys with incident PP cases were identified in 2002, and 7498 girls and 739 boys were identified in 2013. For girls, the incidence rates (per 10,000 person-years) were 16.17 (95% CI 15.55-16.80) and 70.23 (95% CI 68.65-71.83) in 2002 and 2013, respectively. For boys, the incidence rates were 1.09 (95% CI 0.95-1.24) and 5.72 (95% CI 5.32-6.15) in 2002 and 2013, respectively. The sex ratio (F:M) of the incidence of PP cases was 14.89 in 2002 and 12.28 in 2013.
Conclusion:
In this study, from 2000 to 2013, the frequency of visiting pediatric endocrinology outpatient clinics for precocious puberty increased in both genders. We advocate that it is important to pay increased attention to children's health, environmental hormones, and diet. Researchers should consider how to survey precocious puberty and offer parents more education to avoid the waste of medical resources or delays in seeking medical care.
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