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Statin Use Is Associated with Decreased Risk of Invasive Mechanical Ventilation in COVID-19 Patients: A Preliminary

Sophia L Song1, Sarah B Hays1, Constance E Panton1

  • 1Infectious Diseases Division, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.

Pathogens (Basel, Switzerland)
|September 22, 2020
PubMed

Insights

This study found that statin use was associated with a lower risk of invasive mechanical ventilation in hospitalized COVID-19 patients. These findings support the continued use of statins for managing COVID-19 patients with cardiovascular disease.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • COVID-19 severity is increased in patients with cardiovascular disease (CVD).
  • Statins, prescribed for CVD, possess anti-inflammatory and immunomodulatory properties.
  • The impact of statins on COVID-19 outcomes requires further investigation.

Purpose of the Study:

  • To explore the association between statin use and severe COVID-19 outcomes.
  • To analyze the relationship between statin use and intensive care unit (ICU) admission, invasive mechanical ventilation (IMV), and in-hospital death.

Main Methods:

  • Retrospective cohort study of 249 hospitalized COVID-19 patients.
  • Data collected: demographics, medical history, medications, hospital course.
  • Multivariate logistic regression analysis adjusted for key covariates.

Main Results:

  • Statin use was significantly associated with a decreased risk of IMV (aOR = 0.45, 95% CI: 0.20-0.99) after adjustment.
  • No significant association was found for ICU admission or in-hospital death.

Conclusions:

  • Findings suggest statin use may reduce the need for IMV in hospitalized COVID-19 patients.
  • Results support the continued use of statins in COVID-19 patients.
  • Further prospective studies are warranted to confirm these findings and guide management strategies.

Keywords:
COVID-19HMG-CoA reductase inhibitorsICUSARS-CoV2hospitalizationinvasive mechanical ventilationstatins

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