Related Experiment Video
Updated: Dec 8, 2025
05:39
Detection of MicroRNA Expression in the Kidneys of Immunoglobulin A Nephropathic Mice
Published on: July 8, 2020
2.1K
MicroRNA Expression Levels in Patients with Hashimoto Thyroiditis: A Single Centre Study.
Hale O Yilmaz1, Alper H Cebi1, Mustafa Kocak2
1Department of Medical Genetics, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey.
Endocrine, Metabolic & Immune Disorders Drug Targets
|September 22, 2020
Summary
Circulating microRNAs (miRNAs) show altered expression in Hashimoto thyroiditis (HT). Specific miRNAs like miR-375 and miR-451 differ between diagnosis, follow-up, and healthy states, indicating their role in HT progression.
Area of Science:
- Endocrinology
- Molecular Biology
- Immunology
Background:
- Hashimoto thyroiditis (HT) is a common autoimmune thyroid disease.
- MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation.
- Circulating miRNAs are potential biomarkers for various diseases.
Purpose of the Study:
- To investigate circulatory miRNA expression profiles in patients with Hashimoto thyroiditis (HT).
- To compare miRNA levels at diagnosis and during the euthyroid follow-up period against healthy controls.
- To identify specific miRNAs associated with HT.
Main Methods:
- Blood samples were collected from 34 HT patients (at diagnosis and euthyroid phase) and 33 healthy controls.
- Real-time polymerase chain reaction (PCR) was used to quantify five specific circulating miRNAs (miR-22, miR-141, miR-155, miR-375, miR-451).
Main Results:
- Significant differences in miR-375 levels were observed between HT patients at diagnosis and healthy controls.
- miR-451 levels showed significant variation between HT patients at diagnosis and during the euthyroid follow-up phase.
- A positive correlation was found between thyroid-stimulating hormone (TSH) and miR-22 expression in HT patients at diagnosis.
Conclusions:
- Circulating miRNAs play significant roles throughout the disease course of HT.
- These findings suggest that specific miRNAs could serve as biomarkers for HT.
- Further research is warranted across various thyroid and autoimmune diseases.
