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Updated: Dec 8, 2025
Isolation and Culture of Primary Endothelial Cells from Canine Arteries and Veins
Published on: November 18, 2016
Expression of Arginine Vasopressin Type 2 Receptor in Canine Mammary Tumours: Preliminary Results
M A Benavente1, C P Bianchi1, M A Aba1
1Laboratorio de Endocrinología, Centro de Investigación Veterinaria de Tandil, National Council for Scientific and Technical Research, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Buenos Aires, Argentina.
Abstract:
The aims of this study were to investigate the potential association of arginine vasopressin type 2 receptor (AVPR2) in canine mammary tumours with expression of oestrogen receptors α (ORα) and β (ORβ) and clinicopathological features of the neoplasms. Twenty-six canine mammary tumour samples (11 benign, 15 malignant) were immunolabelled for AVPR2, ORα and ORβ antigens. Moderate to intense immunolabelling of AVPR2 antigen, found in all neoplasms, was not significantly associated with expression of ORα or ORβ antigens or with clinicopathological features. These findings indicate a potential role for AVPR2 in the development of canine mammary tumours and the use of AVPR2-selective vasopressin analogues as therapeutic options.
