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Therapeutic Opportunities for Repair GPCRs during Intestinal Mucosal Wound Healing
1Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA.
Abstract:
G protein-coupled receptors (GPCRs) are crucial for establishing the resolution phase following an intestinal inflammatory episode. Because current treatments for intestinal inflammation have a high percentage of failure and lead to immunosuppression, repair GPCRs have promising therapeutic potential because they trigger resolution pathways without compromising the immune response.
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