Antifungal Stewardship in Hematology: Reflection of a Multidisciplinary Group of Experts

Area of Science:

• Infectious Diseases
• Hematology
• Pharmacology

Background:

• Hematology patients often require antifungal therapy due to increased infection risk.
• Existing recommendations for antifungal use in this population are fragmented.
• Managing antifungal agents requires careful consideration of organ function and drug interactions.

Purpose of the Study:

• To consolidate international guidelines on antifungal agents for hematology patients.
• To provide expert recommendations on optimizing antifungal therapy, including dose adjustments and side effect management.
• To create a practical resource for prescribers to ensure safe and effective antifungal use.

Main Methods:

• Development of a practical guide by a working group of experts.
• Synthesis of recommendations from international groups on antifungal agents.
• Inclusion of expert input from nephrology, hepatology, and drug interaction specialists.

Main Results:

• A comprehensive guide summarizing antifungal recommendations for hematology patients.
• Detailed advice on dose adjustments, monitoring, and managing side effects of antifungals.
• Consideration of toxicity and drug interactions tailored to specific indications.

Conclusions:

• The guide facilitates optimal and safer use of antifungal agents in hematology patients.
• Prescribers have a consolidated resource for evidence-based antifungal therapy.
• Improved patient outcomes are expected through informed antifungal management.