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Related Concept Videos

Tumor Immunotherapy01:27

Tumor Immunotherapy

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Hybridoma Technology01:31

Hybridoma Technology

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Hybridoma technology is used for the large-scale production of monoclonal antibodies. Monoclonal antibodies bind to only a single antigenic determinant or epitope. Such antibodies are used in research, diagnostics, and disease therapy. The hybridoma technology established in 1975 by Georges Köhler and Cesar Milstein was awarded the Nobel Prize in Medicine in 1984 for revolutionizing research and therapy.
Hybridoma Selection
Commonly used fusion techniques — electroporation,...
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CD8<sup>+</sup>CD38<sup>+</sup> T cells identify functional high-risk multiple myeloma after autologous transplant: BMT CTN 0702 correlates.

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Concurrent administration of BCMA and GPRC5D chimeric antigen receptor (CAR) T cells in advanced multiple myeloma.

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Patient-Specific Determinants of Response to BCMA- and GPRC5D-Targeted CAR T-Cell Therapy in Multiple Myeloma: A QSP Analysis of Clinical Trial and Real-World Data.

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Related Experiment Video

Updated: Dec 8, 2025

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
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Emerging immunotherapies in multiple myeloma.

Urvi A Shah1, Sham Mailankody2

  • 1Myeloma Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, 530 East 74th Street, New York, NY 10021, USA shahu@mskcc.org.

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|September 22, 2020
PubMed
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Multiple myeloma treatments are advancing with novel immunotherapies. This review details emerging therapies like CAR T-cells and bispecific antibodies targeting B-cell maturation antigen, improving patient outcomes.

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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Related Experiment Videos

Last Updated: Dec 8, 2025

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An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
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Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Multiple myeloma is an incurable plasma cell malignancy despite two decades of treatment advances.
  • Immunotherapy has become a cornerstone in managing multiple myeloma, significantly improving survival rates.
  • Early immunotherapies included allogeneic stem cell transplants and immunomodulatory drugs.

Purpose of the Study:

  • To review the evolving landscape of immunotherapies for multiple myeloma.
  • To summarize the mechanisms of action, safety, and efficacy of novel treatments.
  • To highlight emerging therapeutic targets, including the B-cell maturation antigen.

Main Methods:

  • Literature review of clinical trials and scientific evidence.
  • Analysis of immunotherapeutic agents including monoclonal antibodies, CAR T-cells, and bispecific antibodies.
  • Examination of treatments targeting B-cell maturation antigen and other novel receptors.

Main Results:

  • Immunomodulatory drugs and monoclonal antibodies have demonstrated significant efficacy.
  • Emerging immunotherapies such as chimeric antigen receptor T cells and bispecific antibodies show promise.
  • Targeting the B-cell maturation antigen is a key strategy in current and future therapies.

Conclusions:

  • Multiple myeloma treatment continues to evolve with diverse and effective immunotherapies.
  • Emerging immunotherapies offer new hope and improved outcomes for patients.
  • Ongoing research into novel targets and therapies is crucial for advancing multiple myeloma care.