Related Experiment Video
Updated: Dec 8, 2025
09:24
Repeated Measurement of Respiratory Muscle Activity and Ventilation in Mouse Models of Neuromuscular Disease
Published on: April 17, 2017
13.4K
Ventilator dependence complications in motor neuron disease
Felicity Dewhurst1,2, Joanna Elverson2, Amanda Mccleery2
1Palliative Medicine, Newcastle University, Newcastle upon Tyne, UK drfelicitywerrett@doctors.org.uk.
BMJ Supportive & Palliative Care
|September 22, 2020
Summary
Long-term non-invasive ventilation (NIV) dependence can cause severe complications. This case study shows how a hospice team effectively managed NIV-related issues in a patient with motor neuron disease.
Area of Science:
- Palliative Care
- Respiratory Medicine
- Neurology
Background:
- Long-term non-invasive ventilation (NIV) without advance care planning presents management challenges.
- Patients with respiratory failure requiring prolonged NIV may develop significant complications.
- Motor neuron disease (MND) can necessitate dependence on NIV.
Purpose of the Study:
- To present a case of severe complications arising from long-term NIV dependence.
- To illustrate innovative management strategies for NIV-related issues in a hospice setting.
- To highlight the role of a multidisciplinary team in managing complex patient needs.
Main Methods:
- Case report of a patient with respiratory failure requiring NIV.
- Diagnosis of motor neuron disease during NIV dependence.
- Multidisciplinary hospice team intervention for managing complications.
Main Results:
- Patient developed facial pressure ulceration, nasal septal prolapse, inspissated secretions, and feeding difficulties.
- These complications were effectively managed by the hospice multidisciplinary team.
- External expert support was crucial for acquiring necessary skills and knowledge.
Conclusions:
- NIV dependence can lead to severe, multifaceted complications.
- Hospice multidisciplinary teams can effectively manage these complex issues.
- Collaboration and specialized expertise are vital for successful NIV complication management.
More Related Videos
Related Concept Videos
01:23Mechanical Ventilation II: Invasive Ventilation
478
Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
478
01:29Mechanical Ventilation I: Indication and Settings
2.0K
Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
2.0K
01:30Acute Respiratory Failure-III
584
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
584
01:21Skeletal Muscle Relaxants: Adverse Effects
667
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
Unlike...
667
01:23Mechanical Ventilation III: Noninvasive Ventilation
398
Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation...
Noninvasive Positive-Pressure Ventilation...
398
01:28Depolarizing Blockers: Mechanism of Action
2.4K
Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because...
2.4K