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Updated: Dec 8, 2025

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments
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Protein Glycosylation: "New-yet-Old" Target for Immunotherapy

Jaydeep Bhat1, Dieter Kabelitz2

  • 1Metabolic Programming, TUM School of Life Sciences Weihenstephan; ZIEL-Institute for Food and Health, Technical University of Munich (TUM), Freising, Germany. bhatvjay24@gmail.com dietrich.kabelitz@uksh.de.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|September 22, 2020
PubMed

Insights

Checkpoint monotherapy shows limited cancer treatment success. Exploring protein glycosylation, a post-translational modification, offers new targets for effective combined immunotherapy strategies.

Area of Science:

  • Oncology
  • Immunology
  • Biochemistry

Background:

  • Checkpoint monotherapy has shown limited efficacy in cancer treatment.
  • Post-translational modifications (PTMs) like glycosylation play crucial roles in disease pathology.
  • PTMs regulate immunometabolic gene expression, influencing the tumor microenvironment.

Purpose of the Study:

  • To explore the potential of protein glycosylation as a therapeutic target in cancer.
  • To investigate the role of distinct glycosylation patterns in disease.
  • To identify novel mechanistic targets for combined immunotherapy.

Main Methods:

  • Analysis of distinct protein glycosylation patterns in disease states.
  • Investigating the regulatory role of glycosylation in immunometabolic gene expression.
  • Evaluating glycosylation as a target for enhancing immunotherapy.

Main Results:

  • Specific glycosylation patterns are associated with distinct disease characteristics.
  • Glycosylation significantly influences immunometabolic gene expression.
  • Targeting glycosylation presents a promising strategy for combined immunotherapy.

Conclusions:

  • Protein glycosylation is a critical factor in cancer and immune response.
  • Novel therapeutic strategies can be developed by targeting protein glycosylation.
  • Combined immunotherapy approaches targeting glycosylation may overcome limitations of current treatments.

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