Related Experiment Video
Updated: Dec 8, 2025
05:44
Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
Published on: May 17, 2024
891
EBF1-Correlated Long Non-coding RNA Transcript Levels in 3rd Trimester Maternal Blood and Risk of Spontaneous Preterm
Guoli Zhou1, Claudia Holzman2, Bin Chen3
1Clinical & Translational Sciences Institute, Michigan State University, East Lansing, MI, USA. zhoug@msu.edu.
Reproductive Sciences (Thousand Oaks, Calif.)
|September 22, 2020
Summary
Two long non-coding RNAs (lncRNAs), LINC00870 and LINC00094, in maternal blood are associated with spontaneous preterm birth (sPTB). These EBF1-correlated lncRNAs may serve as novel biomarkers for predicting sPTB risk.
Area of Science:
- Genomics and Transcriptomics
- Reproductive Medicine
- Biomarker Discovery
Background:
- Spontaneous preterm birth (sPTB) is a leading cause of neonatal morbidity and mortality.
- Identifying reliable biomarkers for sPTB prediction before labor onset is crucial for timely intervention.
- The role of long non-coding RNAs (lncRNAs) and their correlation with gene expression, such as EBF1, in sPTB is an emerging area of research.
Purpose of the Study:
- To investigate the association between maternal blood EBF1-correlated lncRNAs and spontaneous preterm birth (sPTB).
- To identify potential lncRNA biomarkers for sPTB prediction and stratification.
Main Methods:
- Analysis of a public gene expression dataset (GSE59491) from maternal blood of a Canadian cohort.
- Identification of differentially expressed lncRNAs in spontaneous preterm birth (sPTB) versus term births using limma moderated t-tests.
- Correlation analysis (Pearson) of differentially expressed lncRNAs with EBF1 mRNA levels and logistic regression to assess sPTB risk.
Main Results:
- Two lncRNA transcripts, LINC00094 and LINC00870, were differentially expressed in the third trimester maternal blood of sPTB cases compared to term births.
- LINC00094 showed a positive correlation with EBF1 mRNA levels (r=0.196), while LINC00870 showed a negative correlation (r=-0.303).
- Elevated levels of LINC00870 (highest tertile) and decreased levels of LINC00094 (lowest tertile) were significantly associated with increased odds of sPTB.
Conclusions:
- LINC00870 and LINC00094 are identified as sPTB-associated, EBF1-correlated lncRNAs in maternal blood.
- These lncRNAs, potentially regulated by EBF1 binding sites in their enhancers, show promise as predictive biomarkers for spontaneous preterm birth.
- Further research in diverse cohorts and laboratory models is warranted to elucidate the regulatory mechanisms of these lncRNAs in sPTB.
More Related Videos
Related Concept Videos
03:18Non-LTR Retrotransposons
12.9K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.9K
01:14Fetal Circulation
2.1K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
2.1K
01:07Teratogenicity
3.8K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.8K