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Related Concept Videos

Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Drug Delivery: Overview01:16

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Enteral Route01:18

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Parentral Nutrition: Centeral and Peripheral Parental Nutrition01:27

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Parenteral Nutrition (PN) delivers essential nutrients directly into the bloodstream, bypassing the digestive system. It is commonly used for individuals with severe digestive disorders or conditions that prevent normal nutrient absorption.
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Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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Needleless or Noninvasive Delivery Technology.

Akshay Datey1, Jagadeesh Gopalan1,2, Dipshikha Chakravortty3,4

  • 1Centre for Biosystems Science & Engineering, Indian Institute of Science, Bangalore, Karnataka, India.

Methods in Molecular Biology (Clifton, N.J.)
|September 22, 2020
PubMed
Summary
This summary is machine-generated.

Needle-free injection systems offer a safer alternative to traditional needles, addressing concerns like pathogen transmission and pain. This technology has evolved significantly since the 1950s, with various needle-less methods now in clinical use.

Keywords:
InjectionsMicroinjectionsNanoparticleNeedle-freeVaccine

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Area of Science:

  • Biomedical Engineering
  • Pharmaceutical Sciences
  • Public Health

Background:

  • Traditional hypodermic needle injections are standard for drug and vaccine delivery from infancy.
  • Needle-based systems pose risks including pathogen transmission (HIV, HBV), needlestick injuries, plastic waste, and patient pain.
  • These drawbacks have driven research into needle-free alternatives since the 1950s.

Purpose of the Study:

  • To review the historical development of needle-free injection technologies.
  • To provide an overview of established needle-less injection methods currently in use.
  • To highlight advancements in alternative drug and vaccine administration systems.

Main Methods:

  • Literature review of historical and contemporary needle-free injection systems.
  • Analysis of technological advancements and clinical applications.
  • Categorization of various needle-less injection methodologies.

Main Results:

  • Significant progress has been made in developing diverse needle-free injection systems.
  • Several needle-less technologies are now established in clinical practice.
  • The evolution reflects a growing demand for safer and more patient-friendly administration methods.

Conclusions:

  • Needle-free injection systems represent a crucial advancement in medical delivery.
  • These technologies mitigate the risks associated with conventional needles.
  • Continued research and development promise further innovation in needle-less drug and vaccine administration.