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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Cancer Therapies02:49

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Related Experiment Video

Updated: Dec 8, 2025

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
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Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

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Cancer stem cell targeted therapies.

Ugo Testa1, Elvira Pelosi1, Germana Castelli1

  • 1Dipartimento di Oncologia, Istituto Superiore di Sanità, Rome, Italy.

Annali Dell'Istituto Superiore Di Sanita
|September 22, 2020
PubMed
Summary

Cancer stem cells (CSCs) drive tumor growth, heterogeneity, and drug resistance. Targeting CSCs offers a promising strategy for novel cancer therapies and potential tumor eradication when combined with conventional treatments.

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Research

Background:

  • Normal tissues rely on stem cells for homeostasis, self-renewal, and differentiation.
  • Recent research indicates the presence of cancer stem cells (CSCs) within tumors, sharing similar properties.

Purpose of the Study:

  • To explore the role of cancer stem cells in tumor initiation, maintenance, and heterogeneity.
  • To investigate the implications of cancer stem cells in drug resistance and tumor recurrence.
  • To evaluate cancer stem cells as therapeutic targets for novel anti-cancer strategies.

Main Methods:

  • Review of recent studies on cancer stem cell properties and functions.
  • Analysis of immunophenotypic markers for CSC identification.
  • Examination of cancer plasticity and its impact on CSC characteristics.

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Main Results:

  • Cancer stem cells initiate and sustain tumor growth, driving intra- and inter-tumoral heterogeneity.
  • CSCs are key mediators of drug resistance, contributing to tumor recurrence and metastasis.
  • Cancer stemness is a dynamic property influenced by cancer plasticity.

Conclusions:

  • Cancer stem cells are critical targets for developing innovative anti-cancer therapies.
  • Combining conventional treatments with CSC-targeting drugs shows potential for complete cancer eradication.
  • Further research supports the clinical utility of targeted CSC strategies in various tumors.