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Thrombo-inflammatory features predicting mortality in patients with COVID-19: The FAD-85 score

Junhong Wang1, Hua Zhang2, Rui Qiao3

  • 1Emergency Department, Peking University Third Hospital, Beijing, China.

The Journal of International Medical Research
|September 22, 2020
PubMed

Insights

Inflammation and hypercoagulation markers like ferritin, tumor necrosis factor-α, D-dimer, and interleukin-6 predict COVID-19 severity and mortality. A FAD-85 score using age, ferritin, and D-dimer aids in risk assessment.

Area of Science:

  • * Medical research
  • * Infectious diseases
  • * Critical care medicine

Background:

  • * The predictive roles of inflammation and hypercoagulation in COVID-19 outcomes remain incompletely understood.
  • * Understanding these factors is crucial for managing the disease's severity and prognosis.

Purpose of the Study:

  • * To investigate the association between thrombo-inflammatory markers and COVID-19 severity and mortality.
  • * To develop a predictive model for 28-day mortality in COVID-19 patients.

Main Methods:

  • * Adult COVID-19 patients were recruited from Tongji Hospital, Wuhan.
  • * Data analysis included univariate analysis and multivariable binary logistic regression.
  • * A predictive score (FAD-85) and nomogram were developed using key parameters.

Main Results:

  • * Elevated ferritin, tumor necrosis factor-α, D-dimer, and decreased albumin were linked to disease severity.
  • * Older age, elevated ferritin, and elevated interleukin-6 predicted 28-day mortality.
  • * The FAD-85 score demonstrated high sensitivity (86.4%), specificity (81.8%), and accuracy (86.4%) in predicting mortality.

Conclusions:

  • * Thrombo-inflammatory markers are vital indicators of COVID-19 severity and prognosis.
  • * These parameters can guide clinical treatment decisions for inflammatory and coagulation abnormalities.
Abstract

Keywords:
COVID-19coagulationinflammationmodelmortalitypredictor

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