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Related Concept Videos

Structural Joints: Fibrous Joints01:03

Structural Joints: Fibrous Joints

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Fibrous joints are a type of joint where the bones are connected by fibrous connective tissue. These joints provide stability and minimal to no movement between the articulating bones. There are three types of fibrous joints.
Suture
All the bones of the skull, except for the mandible, are joined to each other by a fibrous joint called a suture. The fibrous connective tissue found at a suture strongly unites the adjacent skull bones and thus helps to protect the brain and form the face. In...
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Sutures of the Skull01:22

Sutures of the Skull

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The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
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Fibrous Proteins00:55

Fibrous Proteins

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Fibrous proteins are either long and narrow proteins or assemble to form long and thin structures. They contain repetitive units and usually consist of either alpha helices or beta sheets and, in rare cases, a mix of both. The amino acids in the primary structure often consist of repeating amino acid sequences. The role of fibrous proteins is primarily structural. Many are located in the extracellular matrix and are present in connective tissues to impart strength and joint mobility. They are...
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Growth of Cartilage and Bone Tissue01:27

Growth of Cartilage and Bone Tissue

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Chondrocytes form a temporary cartilaginous model by dividing and secreting a thick gel-like extracellular matrix. Once the chondrocytes undergo programmed cell death, osteoblasts enter the site of the cartilaginous model. The process of replacing the temporary cartilaginous model with bone in an ordered manner is called endochondral ossification. In endochondral ossification, not all of the cartilage is replaced by bone tissue. Some cartilage that performs a protective and supportive function...
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Bone Formation by Intramembranous Ossification01:29

Bone Formation by Intramembranous Ossification

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Fibril-associated Collagen01:11

Fibril-associated Collagen

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Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects
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Creating Rigidly Stabilized Fractures for Assessing Intramembranous Ossification, Distraction Osteogenesis, or Healing of Critical Sized Defects

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[Fibrous dysplasia].

Thomas Wirth1

  • 1Klinik für Orthopädie, Klinikum Stuttgart, Olgahospital, Kriegsbergstr. 62, 70176, Stuttgart, Deutschland. t.wirth@klinikum-stuttgart.de.

Der Orthopade
|September 22, 2020
PubMed
Summary
This summary is machine-generated.

Fibrous dysplasia is a benign bone tumor caused by a genetic mutation. Orthopedic treatments can stabilize fractures, strengthen bones, and correct deformities, improving mobility for affected patients.

Keywords:
Benign bone tumorCoxa varaGNAS geneIntramedullary stabilizationMcCune-Albright syndrome

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Area of Science:

  • Orthopedics
  • Genetics
  • Pathology

Background:

  • Fibrous dysplasia is a benign intraosseous tumor.
  • It can manifest as monostotic or polyostotic disease.
  • Associated syndromes include McCune-Albright and Mazabraud's.

Purpose of the Study:

  • To describe the etiology and clinical presentation of fibrous dysplasia.
  • To outline orthopedic treatment strategies for fibrous dysplasia.
  • To highlight the impact of treatment on patient mobility and quality of life.

Main Methods:

  • Review of the genetic basis of fibrous dysplasia (GNAS gene mutation).
  • Description of clinical manifestations, including pain, fractures, and deformities.
  • Overview of orthopedic interventions for fracture stabilization, bone strengthening, and deformity correction.

Main Results:

  • The GNAS gene mutation disrupts osteogenesis, leading to weakened bone.
  • Symptoms range from local pain and fractures to severe bone deformation impacting mobility.
  • Orthopedic treatments can effectively manage symptoms and improve function.

Conclusions:

  • Fibrous dysplasia is a genetically determined condition affecting bone integrity.
  • Prompt and appropriate orthopedic management is crucial for improving patient outcomes.
  • Treatment can significantly enhance pain-free mobility and quality of life, even in severe cases.